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- Title
Effects of glutamate NMDA and TRPV1 receptor antagonists on the biphasic responses to anandamide injected into the dorsolateral periaqueductal grey of Wistar rats.
- Authors
Fogaça, Manoela V; Gomes, Felipe V; Moreira, Fabrício A; Guimarães, Francisco S; Aguiar, Daniele C
- Abstract
The endocannabinoid and endovanniloid anandamide (AEA) exerts biphasic effects when injected into the dorsolateral periaqueductal grey (dlPAG) in rats submitted to threatening situations. Whereas lower doses of AEA induce anxiolytic-like effects by activating cannabinoid CB1 receptors, no effects are observed with higher doses, possibly due to the simultaneous activation of transient receptor potential vanilloid type 1 (TRPV1) receptors. This activation would facilitate glutamatergic neurotransmission.
- Publication
Psychopharmacology, 2013, Vol 226, Issue 3, p579
- ISSN
1432-2072
- Publication type
Journal Article
- DOI
10.1007/s00213-012-2927-2