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- Title
Persistent effects of prior chronic exposure to corticosterone on reward-related learning and motivation in rodents.
- Authors
Olausson, Peter; Kiraly, Drew D; Gourley, Shannon L; Taylor, Jane R
- Abstract
Repeated or prolonged exposure to stress has profound effects on a wide spectrum of behavioral and neurobiological processes and has been associated with the pathophysiology of depression. The multifaceted nature of this disorder includes despair, anhedonia, diminished motivation, and disrupted cognition, and it has been proposed that depression is also associated with reduced reward-motivated learning. We have previously reported that prior chronic corticosterone exposure to mice produces a lasting depressive-like state that can be reversed by chronic antidepressant treatment.
- Publication
Psychopharmacology, 2013, Vol 225, Issue 3, p569
- ISSN
1432-2072
- Publication type
Journal Article
- DOI
10.1007/s00213-012-2844-4