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- Title
Varenicline decreases alcohol consumption in heavy-drinking smokers.
- Authors
Mitchell, Jennifer M; Teague, Candice H; Kayser, Andrew S; Bartlett, Selena E; Fields, Howard L
- Abstract
Emerging evidence suggests that the α4β2 form of the nicotinic acetylcholine receptor (nAChR) modulates the rewarding effects of alcohol. The nAChR α4β2 subunit partial agonist varenicline (Chantix™), which is approved by the Food and Drug Administration for smoking cessation, also decreases ethanol consumption in rodents (Steensland et al., Proc Natl Acad Sci U S A 104:12518-12523, 2007) and in human laboratory and open-label studies (Fucito et al., Psychopharmacology (Berl) 215:655-663, 2011; McKee et al., Biol Psychiatry 66:185-190 2009).
- Publication
Psychopharmacology, 2012, Vol 223, Issue 3, p299
- ISSN
1432-2072
- Publication type
Journal Article
- DOI
10.1007/s00213-012-2717-x