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- Title
Effects of AZD3480, a neuronal nicotinic acetylcholine receptor agonist, and donepezil on dizocilpine-induced attentional impairment in rats.
- Authors
Rezvani, Amir H; Cauley, Marty C; Johnson, Edwin C; Gatto, Gregory J; Levin, Edward D
- Abstract
Nicotinic acetylcholine systems play major roles in cognitive function. Nicotine and a variety of nicotinic agonists improve attention, and nicotinic antagonist exposure impairs it. This study was conducted to investigate the effect of a novel nicotinic receptor agonist at α4β2 nicotinic receptors (AZD3480) on attention and reversal of pharmacologically induced attentional impairment produced by the NMDA glutamate antagonist dizocilpine (MK-801).
- Publication
Psychopharmacology, 2012, Vol 223, Issue 3, p251
- ISSN
1432-2072
- Publication type
Journal Article
- DOI
10.1007/s00213-012-2712-2