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- Title
Assessing the effects of chronic sazetidine-A delivery on nicotine self-administration in both male and female rats.
- Authors
Johnson, Joshua E; Slade, Susan; Wells, Corinne; Petro, Ann; Sexton, Hannah; Rezvani, Amir H; Brown, Milton L; Paige, Mikell A; McDowell, Brian E; Xiao, Yingxian; Kellar, Kenneth J; Levin, Edward D
- Abstract
Sazetidine-A is a selective α4β2 nicotinic receptor desensitizing agent and partial agonist. It has been shown in previous studies to significantly reduce nicotine self-administration in rats after acute or repeated injections. However, the effects of continuous chronic infusions of sazetidine-A on maintenance of nicotine self-administration and relapse after abstinence have yet to be examined.
- Publication
Psychopharmacology, 2012, Vol 222, Issue 2, p269
- ISSN
1432-2072
- Publication type
Journal Article
- DOI
10.1007/s00213-012-2642-z