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- Title
Phosphodiesterase 4 inhibition enhances the dopamine D1 receptor/PKA/DARPP-32 signaling cascade in frontal cortex.
- Authors
Kuroiwa, Mahomi; Snyder, Gretchen L; Shuto, Takahide; Fukuda, Atsuo; Yanagawa, Yuchio; Benavides, David R; Nairn, Angus C; Bibb, James A; Greengard, Paul; Nishi, Akinori
- Abstract
Alteration of dopamine neurotransmission in the prefrontal cortex, especially hypofunction of dopamine D1 receptors, contributes to psychotic symptoms and cognitive deficit in schizophrenia. D1 receptors signal through the cAMP/PKA second messenger cascade, which is modulated by phosphodiesterase (PDE) enzymes that hydrolyze and inactivate cyclic nucleotides. Though several PDEs are expressed in cortical neurons, the PDE4 enzyme family (PDE4A-D) has been implicated in the control of cognitive function. The best studied isoform, PDE4B, interacts with a schizophrenia susceptibility factor, disrupted in schizophrenia 1 (DISC1).
- Publication
Psychopharmacology, 2012, Vol 219, Issue 4, p1065
- ISSN
1432-2072
- Publication type
Journal Article
- DOI
10.1007/s00213-011-2436-8