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Title
Antidepressant-like properties of oral riluzole and utility of incentive disengagement models of depression in mice.
Authors
Gourley, Shannon L; Espitia, Jonathan W; Sanacora, Gerard; Taylor, Jane R
Abstract
The neuroprotective agent riluzole has antidepressant-like properties in humans, but its mechanisms of action are unclear. Despite the increasing utility of transgenic and knockout mice in addressing such issues, previous studies aimed at characterizing biochemical mechanisms have been conducted in rats.