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- Title
Translational PK-PD modelling of molecular target modulation for the AMPA receptor positive allosteric modulator Org 26576.
- Authors
Bursi, Roberta; Erdemli, Gul; Campbell, Robert; Hutmacher, Matthew M; Kerbusch, Thomas; Spanswick, David; Jeggo, Ross; Nations, Kari R; Dogterom, Peter; Schipper, Jacques; Shahid, Mohammed
- Abstract
The α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) receptor potentiator Org 26576 represents an interesting pharmacological tool to evaluate the utility of glutamatergic enhancement towards the treatment of psychiatric disorders. In this study, a rat-human translational pharmacokinetic-pharmacodynamic (PK-PD) model of AMPA receptor modulation was used to predict human target engagement and inform dose selection in efficacy clinical trials.
- Publication
Psychopharmacology, 2011, Vol 218, Issue 4, p713
- ISSN
1432-2072
- Publication type
Journal Article
- DOI
10.1007/s00213-011-2365-6