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- Title
Central mediation and differential blockade by cannabinergics of the discriminative stimulus effects of the cannabinoid CB1 receptor antagonist rimonabant in rats.
- Authors
Järbe, Torbjörn U C; LeMay, Brian J; Vemuri, V Kiran; Vadivel, Subramanian K; Zvonok, Alexander; Makriyannis, Alexandros
- Abstract
Discovery of an endocannabinoid signaling system launched the development of the blocker rimonabant, a cannabinoid CB1 receptor (CB(1)R) antagonist/inverse agonist. Due to untoward effects, this medication was withdrawn and efforts have been directed towards discovering chemicals with more benign profiles.
- Publication
Psychopharmacology, 2011, Vol 216, Issue 3, p355
- ISSN
1432-2072
- Publication type
Journal Article
- DOI
10.1007/s00213-011-2226-3