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- Title
Effects of cocaine hydrolase on cocaine self-administration under a PR schedule and during extended access (escalation) in rats.
- Authors
Carroll, Marilyn E; Gao, Yang; Brimijoin, Stephen; Anker, Justin J
- Abstract
Previously, Albu-CocH, a cocaine hydrolase derived from human butyrylcholinesterase, blocked cocaine-induced reinstatement of drug seeking in rats. In the present study, rats were treated with Albu-CocH while self-administering cocaine under a progressive ratio (PR) schedule during 2-h sessions and under a fixed-ratio 1 (FR 1) schedule during 6-h sessions.
- Publication
Psychopharmacology, 2011, Vol 213, Issue 4, p817
- ISSN
1432-2072
- Publication type
Journal Article
- DOI
10.1007/s00213-010-2040-3