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- Title
Impact of metabotropic glutamate 2/3 receptor stimulation on activated dopamine release and locomotion.
- Authors
Pehrson, Alan L; Moghaddam, Bita
- Abstract
Activation of metabotropic glutamate (mGlu) 2/3 receptors may provide a novel strategy for treating schizophrenia. This effect is thought to be mediated through dopamine-independent mechanisms because mGlu2/3-receptor agonists have no considerable affinity for dopamine receptors. These agonists, however, reduce amphetamine-induced hyperlocomotion suggesting that they influence dopamine neurotransmission.
- Publication
Psychopharmacology, 2010, Vol 211, Issue 4, p443
- ISSN
1432-2072
- Publication type
Journal Article
- DOI
10.1007/s00213-010-1914-8