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- Title
Comparison of the kappa-opioid receptor antagonist DIPPA in tests of anxiety-like behavior between Wistar Kyoto and Sprague Dawley rats.
- Authors
Carr, Gregory V; Lucki, Irwin
- Abstract
Recent evidence suggests a role for the dynorphin/kappa-opioid receptor (KOR) system in the expression of stress-induced behaviors. Wistar Kyoto (WKY) rats exhibit increased depression-like and anxiety-like responses in behavioral tests compared to other strains and may be a model of comorbid depression and anxiety characterized by increased activity within the dynorphin/KOR system. Though KOR antagonists produce antidepressant-like effects in WKY rats, their effects in tests of anxiety-like behavior have not been examined in the WKY strain.
- Publication
Psychopharmacology, 2010, Vol 210, Issue 2, p295
- ISSN
1432-2072
- Publication type
Journal Article
- DOI
10.1007/s00213-010-1832-9