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- Title
Pharmacological modulators of nitric oxide signaling and contextual fear conditioning in mice.
- Authors
Kelley, Jonathan B; Anderson, Karen L; Itzhak, Yossef
- Abstract
Nitric oxide (NO) produced by neuronal nitric oxide synthase (nNOS) is a retrograde neuronal messenger that participates in synaptic plasticity, including late-phase long-term potentiation (LTP) and long-term memory (LTM) formation. Our recent studies have shown that nNOS knockout (KO) mice have a severe deficit in contextual fear conditioning compared to wild type (WT) counterparts (Kelley et al. 2009).
- Publication
Psychopharmacology, 2010, Vol 210, Issue 1, p65
- ISSN
1432-2072
- Publication type
Journal Article
- DOI
10.1007/s00213-010-1817-8