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- Title
The serotonin 2C receptor potently modulates the head-twitch response in mice induced by a phenethylamine hallucinogen.
- Authors
Canal, Clinton E; Olaghere da Silva, Uade B; Gresch, Paul J; Watt, Erin E; Sanders-Bush, Elaine; Airey, David C
- Abstract
Hallucinogenic serotonin 2A (5-HT(2A)) receptor partial agonists, such as (+ or -)-1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane hydrochloride (DOI), induce a frontal cortex-dependent head-twitch response (HTR) in rodents, a behavioral proxy of a hallucinogenic response that is blocked by 5-HT(2A) receptor antagonists. In addition to 5-HT(2A) receptors, DOI and most other serotonin-like hallucinogens have high affinity and potency as partial agonists at 5-HT(2C) receptors.
- Publication
Psychopharmacology, 2010, Vol 209, Issue 2, p163
- ISSN
1432-2072
- Publication type
Journal Article
- DOI
10.1007/s00213-010-1784-0