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- Title
Effects of kappa opioids in an assay of pain-depressed intracranial self-stimulation in rats.
- Authors
Negus, S Stevens; Morrissey, Ember M; Rosenberg, Marisa; Cheng, K; Rice, Kenner C
- Abstract
Selective, centrally acting kappa opioid agonists produce antinociception in a wide range of preclinical assays, but these compounds perform poorly as analgesics in humans. This discrepancy may be related to the behavioral depressant effects of kappa agonists. Kappa antagonists do not typically produce antinociception, but they produce antidepressant-like effects in some preclinical assays.
- Publication
Psychopharmacology, 2010, Vol 210, Issue 2, p149
- ISSN
1432-2072
- Publication type
Journal Article
- DOI
10.1007/s00213-009-1770-6