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- Title
Selective phosphodiesterase inhibitors: a promising target for cognition enhancement.
- Authors
Reneerkens, Olga A H; Rutten, Kris; Steinbusch, Harry W M; Blokland, Arjan; Prickaerts, Jos
- Abstract
One of the major complaints most people face during aging is an impairment in cognitive functioning. This has a negative impact on the quality of daily life and is even more prominent in patients suffering from neurodegenerative and psychiatric disorders including Alzheimer's disease, schizophrenia, and depression. So far, the majority of cognition enhancers are generally targeting one particular neurotransmitter system. However, recently phosphodiesterases (PDEs) have gained increased attention as a potential new target for cognition enhancement. Inhibition of PDEs increases the intracellular availability of the second messengers cGMP and/or cAMP.
- Publication
Psychopharmacology, 2009, Vol 202, Issue 1-3, p419
- ISSN
1432-2072
- Publication type
Journal Article
- DOI
10.1007/s00213-008-1273-x