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Title
Administration of the calcineurin inhibitor cyclosporine modulates cocaine-induced locomotor activity in rats.
Authors
Addy, Nii A; Bahi, Amine; Taylor, Jane R; Picciotto, Marina R
Abstract
Cocaine administration in rats increases locomotor activity as a result of underlying changes in neurotransmitter dynamics and intracellular signaling. The serine/ threonine phosphatase, calcineurin, is known to modulate several signaling proteins that can influence behavioral responses to cocaine.