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- Title
Involvement of 5HT1A receptors in the anxiolytic-like effects of cannabidiol injected into the dorsolateral periaqueductal gray of rats.
- Authors
Campos, Alline Cristina; Guimarães, Francisco Silveira
- Abstract
Cannabidiol (CBD) is a non-psychotomimetic constituent of Cannabis sativa plant that induces anxiolytic effects. However, the brain sites and mechanisms of these effects remain poorly understood. The dorsolateral periaqueductal gray (dlPAG) is a midbrain structure related to anxiety that contains receptors proposed to interact with CBD such as 5HT1A. In addition, since CBD has been shown to inhibit anandamide metabolism, CB1 receptors could also be involved in the effects of this cannabinoid.
- Publication
Psychopharmacology, 2008, Vol 199, Issue 2, p223
- ISSN
0033-3158
- Publication type
Journal Article
- DOI
10.1007/s00213-008-1168-x