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- Title
A schizophrenia-linked mutation in PIP5K2A fails to activate neuronal M channels.
- Authors
Fedorenko, Olga; Strutz-Seebohm, Nathalie; Henrion, Ulrike; Ureche, Oana N; Lang, Florian; Seebohm, Guiscard; Lang, Undine E
- Abstract
Evidence for an association between phosphatidylinositol-4-phosphate 5-kinase II alpha (PIP5K2A) and schizophrenia was recently obtained and replicated in several samples. PIP5K2A controls the function of KCNQ channels via phosphatidylinositol-4,5-bisphosphate (PIP2) synthesis. Interestingly, recent data suggest that KCNQ channels suppress basal activity of dopaminergic neurons and dopaminergic firing. Activation of KCNQ accordingly attenuates the central stimulating effects of dopamine, cocaine, methylphenidate, and phenylcyclidine.
- Publication
Psychopharmacology, 2008, Vol 199, Issue 1, p47
- ISSN
0033-3158
- Publication type
Journal Article
- DOI
10.1007/s00213-008-1095-x