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- Title
The scopolamine-reversal paradigm in rats and monkeys: the importance of computer-assisted operant-conditioning memory tasks for screening drug candidates.
- Authors
Buccafusco, Jerry J; Terry, Alvin V, Jr; Webster, Scott J; Martin, Daniel; Hohnadel, Elizabeth J; Bouchard, Kristy A; Warner, Samantha E
- Abstract
The scopolamine-reversal model is enjoying a resurgence of interest in clinical studies as a reversible pharmacological model for Alzheimer's disease (AD). The cognitive impairment associated with scopolamine is similar to that in AD. The scopolamine model is not simply a cholinergic model, as it can be reversed by drugs that are noncholinergic cognition-enhancing agents.
- Publication
Psychopharmacology, 2008, Vol 199, Issue 3, p481
- ISSN
0033-3158
- Publication type
Journal Article
- DOI
10.1007/s00213-007-0887-8