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- Title
Acute or subchronic clozapine treatment does not ameliorate prepulse inhibition (PPI) deficits in CPB-K mice with low levels of hippocampal NMDA receptor density.
- Authors
Wolf, Rainer; Paelchen, Katrin; Matzke, Kay; Dobrowolny, Henrik; Bogerts, Bernhard; Schwegler, Herbert
- Abstract
The hypo-glutamatergic hypothesis of schizophrenia is based on clinical similarities between schizophrenia and phencyclidine (PCP)-induced psychosis in mentally healthy humans. Sensorimotor gating, as measured by prepulse inhibition (PPI) of the acoustic startle response (ASR), is impaired in schizophrenic patients. In animals, noncompetitive N-methyl-D: -aspartate (NMDA) antagonists such as PCP disrupt PPI in a way that resembles the defect seen in schizophrenia. In a previous study with inbred mouse strains, low PPI levels have been demonstrated in CPB-K mice possessing low levels of hippocampal NMDA receptor densities. The present study was performed to test whether the low magnitude of PPI in CPB-K mice can be reversed by the atypical antipsychotic drug clozapine (CLZ).
- Publication
Psychopharmacology, 2007, Vol 194, Issue 1, p93
- ISSN
0033-3158
- Publication type
Journal Article
- DOI
10.1007/s00213-007-0824-x