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- Title
Role of atypical opiates in OCD. Experimental approach through the study of 5-HT(2A/C) receptor-mediated behavior.
- Authors
Rojas-Corrales, M Olga; Gibert-Rahola, Juan; Mico, Juan A
- Abstract
The selective serotonin (5-HT) reuptake inhibitors (SSRIs) represent the first-line pharmacotherapy for obsessive-compulsive disorder (OCD), and atypical antipsychotic drugs, which block 5-HT2A receptors, are used in augmentation strategies. Opiate drugs are also effective in treatment-refractory OCD and Tourette syndrome. The 5-HT2A-related behavior (i.e., head twitch) has been related with tics, stereotypes, and compulsive symptoms observed in Tourette syndrome and OCD.
- Publication
Psychopharmacology, 2007, Vol 190, Issue 2, p221
- ISSN
0033-3158
- Publication type
Journal Article
- DOI
10.1007/s00213-006-0619-5