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Title
Long-term effects of developmental PCP administration on sensorimotor gating in male and female rats.
Authors
Rasmussen, Bruce A; O'Neil, Jahn; Manaye, Kebreten F; Perry, David C; Tizabi, Yousef
Abstract
Acutely administered N-methyl-D-asparate (NMDA) antagonists are used to model schizophrenia, as measured by impairments in sensorimotor gating reflected in decreases in prepulse inhibition of the startle response (PPI). Aspects of acute NMDA receptor antagonism limit the applications of these models.