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- Title
Comparison of pramipexole and amisulpride on alertness, autonomic and endocrine functions in healthy volunteers.
- Authors
Samuels, E R; Hou, R H; Langley, R W; Szabadi, E; Bradshaw, C M
- Abstract
In a previous study in healthy volunteers, the anti-Parkinsonian drug pramipexole caused sedation and pupil dilatation, consistent with the stimulation of inhibitory D(2)/D(3) autoreceptors on the ventral tegmental area dopaminergic neurones. The sedation may be related to the removal of the dopaminergic excitation of the locus coeruleus (via the meso-coerulear pathway), whereas the pupil dilatation may be due to the removal of the dopaminergic excitation of the Edinger-Westphal nucleus (via a putative meso-pupillomotor pathway).
- Publication
Psychopharmacology, 2006, Vol 187, Issue 4, p498
- ISSN
0033-3158
- Publication type
Journal Article
- DOI
10.1007/s00213-006-0443-y