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- Title
A model for antipsychotic-induced obesity in the male rat.
- Authors
Minet-Ringuet, Julie; Even, Patrick C; Lacroix, Magali; Tomé, Daniel; de Beaurepaire, Renaud
- Abstract
Weight gain is a common and severe side effect of antipsychotic drugs. A usual tool to study the side effects of psychotropic drugs is animal models. However, attempts to create an animal model of antipsychotic-induced weight gain were not successful so far. Female rodents are sensitive to the effects of antipsychotics, but not males. This does not match the human clinical situation. Antipsychotics have different pharmacokinetic properties in rats and humans, and rats and humans have different spontaneous diets.
- Publication
Psychopharmacology, 2006, Vol 187, Issue 4, p447
- ISSN
0033-3158
- Publication type
Journal Article
- DOI
10.1007/s00213-006-0433-0