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- Title
An mGluR2/3 antagonist, MGS0039, exerts antidepressant and anxiolytic effects in behavioral models in rats.
- Authors
Yoshimizu, Takao; Shimazaki, Toshiharu; Ito, Akie; Chaki, Shigeyuki
- Abstract
Abnormalities of glutamatergic neurotransmission have been reportedly observed in psychiatric disorders. Previously, we demonstrated that (1R, 2R, 3R, 5R, 6R)-2-Amino-3-(3,4-dichlorobenzyloxy)-6-fluorobicyclo[3.1.0]hexane-2,6-dicarboxylic acid (MGS0039) is a selective antagonist for group II metabotropic glutamate receptors (mGluR2/3), and that it exerted antidepressant effects in some animal behavioral tests.
- Publication
Psychopharmacology, 2006, Vol 186, Issue 4, p587
- ISSN
0033-3158
- Publication type
Journal Article
- DOI
10.1007/s00213-006-0390-7