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- Title
Progesterone's effects to reduce anxiety behavior of aged mice do not require actions via intracellular progestin receptors.
- Authors
Frye, C A; Sumida, K; Dudek, B C; Harney, J P; Lydon, J P; O'Malley, B W; Pfaff, D W; Rhodes, M E
- Abstract
Aging is associated with reduced secretion of, and down-regulation of receptors for, progesterone (P); yet, P's effects when administered to younger and older animals have not been systematically investigated. Some of P's antianxiety effects may be due to its conversion to 3alpha-hydroxy-5alpha-pregnan-20-one (3alpha,5alpha-THP) and its subsequent actions as a positive modulator at GABAA receptor complexes (GBRs).
- Publication
Psychopharmacology, 2006, Vol 186, Issue 3, p312
- ISSN
0033-3158
- Publication type
Journal Article
- DOI
10.1007/s00213-006-0309-3