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Title
The effect of the mGlu5 receptor antagonist MPEP in rodent tests of anxiety and cognition: a comparison.
Authors
Ballard, Theresa M; Woolley, Marie L; Prinssen, Eric; Huwyler, Jörg; Porter, Richard; Spooren, Will
Abstract
Antagonists at the metabotropic glutamate 5 (mGlu5) receptor produce robust anxiolytic effects in a number of rat tests. However, there is evidence that mGlu5 receptor antagonists may also impair working memory and spatial learning following intracerebroventricular administration.