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- Title
Topiramate does not alter expression in rat brain of enzymes of arachidonic acid metabolism.
- Authors
Ghelardoni, Sandra; Bazinet, Richard P; Rapoport, Stanley I; Bosetti, Francesca
- Abstract
When administered chronically to rats, drugs that are effective in bipolar disorder-lithium and the anticonvulsants, valproic acid and carbamazepine-have been shown to downregulate the expression of certain enzymes involved in brain arachidonic acid (AA) release and cyclooxygenase (COX)-mediated metabolism. Phase II clinical trials with the anticonvulsant topiramate [2,3:4,5-bis-O-(1-methylethylidene)-beta-D-fructopyranose sulfamate] suggest that this drug may also be effective for bipolar disorder.
- Publication
Psychopharmacology, 2005, Vol 180, Issue 3, p523
- ISSN
0033-3158
- Publication type
Journal Article
- DOI
10.1007/s00213-005-2189-3