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- Title
N-acetylcysteine augmentation in serotonin reuptake inhibitor refractory obsessive-compulsive disorder.
- Authors
Lafleur, Daniel L; Pittenger, Christopher; Kelmendi, Ben; Gardner, Tom; Wasylink, Suzanne; Malison, Robert T; Sanacora, Gerard; Krystal, John H; Coric, Vladimir
- Abstract
Dysfunction of glutamatergic neurotransmission has been implicated in the pathophysiology of obsessive-compulsive disorder (OCD) and recent clinical reports suggest that some glutamate modulating agents are efficacious in the treatment of this disorder. N-acetylcysteine (NAC) is a readily available amino acid compound that is thought to attenuate glutamatergic neurotransmission. NAC may be useful in treating psychiatric disorders involving glutamatergic dysfunction such as OCD.
- Publication
Psychopharmacology, 2006, Vol 184, Issue 2, p254
- ISSN
0033-3158
- Publication type
Case Study
- DOI
10.1007/s00213-005-0246-6