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- Title
A single injection of the kappa opioid antagonist norbinaltorphimine increases ethanol consumption in rats.
- Authors
Mitchell, Jennifer M; Liang, Marisa T; Fields, Howard L
- Abstract
Kappa opioid receptor (KOR) agonists interfere with the reinforcing effects of drugs of abuse. KOR agonists decrease heroin, cocaine, and ethanol self-administration, and block heroin and cocaine conditioned place preference (CPP) in rats. However, KOR agonists also produce emesis and dysphoria, making it difficult to determine if their effects on self-administration are due to an action on reward mechanisms or are secondary to the drug's direct aversive effects. Assuming that endogenous KOR ligands modulate circuits involved in drug and alcohol reward, selective KOR antagonists can be used to clarify these issues. If KOR antagonists increase drug self-administration then it is likely that endogenous KOR agonists directly modulate drug intake.
- Publication
Psychopharmacology, 2005, Vol 182, Issue 3, p384
- ISSN
0033-3158
- Publication type
Journal Article
- DOI
10.1007/s00213-005-0067-7