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- Title
Phenotypic studies on dopamine receptor subtype and associated signal transduction mutants: insights and challenges from 10 years at the psychopharmacology-molecular biology interface.
- Authors
Waddington, John L; O'Tuathaigh, Colm; O'Sullivan, Gerard; Tomiyama, Katsunori; Koshikawa, Noriaki; Croke, David T
- Abstract
Mutants with targeted gene deletion ('knockout') or insertion (transgenic) of D1, D2, D3, D4 and D5 dopamine (DA) receptor subtypes are complemented by an increasing variety of double knockout and transgenic-'knockout' models, together with knockout of critical components of DA receptor signalling cascades such as G alpha(olf)[G gamma7], adenylyl cyclase type 5, PKA [RIIbeta] and DARPP-32. However, it is increasingly recognised that these molecular techniques have a number of inherent limitations. Furthermore, there are poorly understood methodological factors that contribute to inconsistent phenotypic findings between laboratories.
- Publication
Psychopharmacology, 2005, Vol 181, Issue 4, p611
- ISSN
0033-3158
- Publication type
Journal Article
- DOI
10.1007/s00213-005-0058-8