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- Title
Fluvoxamine, a selective serotonin reuptake inhibitor, suppresses tetrahydrobiopterin levels and dopamine as well as serotonin turnover in the mesoprefrontal system of mice.
- Authors
Miura, H; Qiao, H; Kitagami, T; Ohta, T; Ozaki, N
- Abstract
Tetrahydrobiopterin (BH4) is a coenzyme of tyrosine hydroxylase (TH) and tryptophan hydroxylase (TPH), rate-limiting enzymes of monoamine biosynthesis. According to the monoamine hypothesis of depression, antidepressants will restore the function of the brain monoaminergic system, and BH4 concentration.
- Publication
Psychopharmacology, 2005, Vol 177, Issue 3, p307
- ISSN
0033-3158
- Publication type
Journal Article
- DOI
10.1007/s00213-004-1959-7