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- Title
Escitalopram versus citalopram: the surprising role of the R-enantiomer.
- Authors
Sánchez, Connie; Bøgesø, Klaus P; Ebert, Bjarke; Reines, Elin Heldbo; Braestrup, Claus
- Abstract
Citalopram is a racemate consisting of a 1:1 mixture of the R(-)- and S(+)-enantiomers. Non-clinical studies show that the serotonin reuptake inhibitory activity of citalopram is attributable to the S-enantiomer, escitalopram. A series of recent non-clinical and clinical studies comparing escitalopram and citalopram to placebo found that equivalent doses of these two drugs, i.e. containing the same amount of the S-enantiomer, showed better effect for escitalopram. These results suggested that the R-citalopram in citalopram inhibits the effect of the S-enantiomer.
- Publication
Psychopharmacology, 2004, Vol 174, Issue 2, p163
- ISSN
0033-3158
- Publication type
Journal Article
- DOI
10.1007/s00213-004-1865-z