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- Title
Reduced hypophagic effects of d-fenfluramine and the 5-HT2C receptor agonist mCPP in 5-HT1B receptor knockout mice.
- Authors
Lee, Michelle D; Somerville, Elizabeth M; Kennett, Guy A; Dourish, Colin T; Clifton, Peter G
- Abstract
The possible role of compensatory changes in 5-HT2C receptors in the reduced hypophagic action of d-fenfluramine in 5-HT1B knockout (KO) mice was assessed by comparing their response to d-fenfluramine and the 5-HT2C receptor agonist mCPP. In addition we measured 5-HT(2C/A) receptor binding in 5-HT1B KO and wild-type (WT) mice and examined the effects of 5-HT1B receptor antagonists on d-fenfluramine-induced hypophagia in WT mice.
- Publication
Psychopharmacology, 2004, Vol 176, Issue 1, p39
- ISSN
0033-3158
- Publication type
Journal Article
- DOI
10.1007/s00213-004-1864-0