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- Title
Effects of acute and chronic buspirone on impulsive choice and efflux of 5-HT and dopamine in hippocampus, nucleus accumbens and prefrontal cortex.
- Authors
Liu, Y P; Wilkinson, L S; Robbins, T W
- Abstract
Reduced central serotonin (5-HT) activity has been associated with impulsive choice behaviour, but there is no consensus about the precise nature of these effects. Behavioural and neurochemical effects of 5-HT(1A) agonists such as buspirone depend critically on the dose and the duration of treatment. We thus undertook a parametric study of the effects of acute and chronic buspirone on the performance on a test of delayed gratification, as well as on the efflux of serotonin and dopamine (DA) in cortical and subcortical regions in rats.
- Publication
Psychopharmacology, 2004, Vol 173, Issue 1-2, p175
- ISSN
0033-3158
- Publication type
Journal Article
- DOI
10.1007/s00213-003-1726-1