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- Title
The opioid antagonist naltrexone reduces the reinforcing effects of Delta 9 tetrahydrocannabinol (THC) in squirrel monkeys.
- Authors
Justinova, Zuzana; Tanda, Gianluigi; Munzar, Patrik; Goldberg, Steven R
- Abstract
Experimental evidence from animal studies suggests reciprocal functional interactions between endogenous brain cannabinoid and opioid systems. There is recent evidence for a role of the opioid system in the modulation of the reinforcing effects of synthetic cannabinoid CB1 receptor agonists in rodents. Since Delta(9)-tetrahydrocannabinol (THC), the natural psychoactive ingredient in marijuana, is actively and persistently self-administered by squirrel monkeys, this provides an opportunity to directly study involvement of opioid systems in the reinforcing effects of THC in non-human primates.
- Publication
Psychopharmacology, 2004, Vol 173, Issue 1-2, p186
- ISSN
0033-3158
- Publication type
Journal Article
- DOI
10.1007/s00213-003-1693-6