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- Title
Flumazenil and tacrine increase the effectiveness of ondansetron on scopolamine-induced impairment of spatial learning in rats.
- Authors
Diez-Ariza, M; Redondo, C; García-Alloza, M; Lasheras, B; Del Río, J; Ramírez, M J
- Abstract
Cholinergic receptor blockade produces memory deficits in animal models. These deficits can be prevented by 5-HT3 receptor antagonists, such as ondansetron, which increases acetylcholine release. We investigated the effects on cognitive performance of combined treatments of ondansetron with either flumazenil, a GABA(A) receptor benzodiazepine site antagonist, or tacrine, a cholinesterase inhibitor, which are also able to prevent scopolamine-induced cognitive impairment.
- Publication
Psychopharmacology, 2003, Vol 169, Issue 1, p35
- ISSN
0033-3158
- Publication type
Journal Article
- DOI
10.1007/s00213-003-1467-1