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- Title
Effects of amantadine and bromocriptine on startle and sensorimotor gating: parametric studies and cross-species comparisons.
- Authors
Swerdlow, Neal R; Stephany, Nora; Shoemaker, Jody M; Ross, Laura; Wasserman, Lindsay C; Talledo, Jo; Auerbach, Pamela P
- Abstract
We recently reported that prepulse inhibition (PPI) in humans was increased by the dopamine (DA) agonist/ N-methyl- D-aspartate (NMDA) antagonist amantadine (200 mg), but was not significantly altered by the DA agonist bromocriptine (1.25-2.5 mg). PPI-enhancing effects of DA agonists occur in rats under specific stimulus conditions, including short prepulse intervals (<30 ms). We characterized the effects of amantadine and bromocriptine on PPI across species, assessing: (1) dose-response effects on PPI in rats over 10- to 120-ms prepulse intervals; (2) drug effects on PPI in humans, using this same range of prepulse intervals; and (3) drug effects on measures related to PPI, including PPI of perceived stimulus intensity (PPIPSI), and startle habituation.
- Publication
Psychopharmacology, 2002, Vol 164, Issue 1, p82
- ISSN
0033-3158
- Publication type
Journal Article
- DOI
10.1007/s00213-002-1172-5