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Title
Bupropion occupancy of the dopamine transporter is low during clinical treatment.
Authors
Meyer, Jeffrey H; Goulding, Verdell S; Wilson, Alan A; Hussey, Doug; Christensen, Bruce K; Houle, Sylvain
Abstract
Bupropion is thought to treat major depression by blocking the dopamine transporter (DAT) because bupropion appears to have a selective affinity for the DAT. The validity of this mechanism has been questioned because the affinity of bupropion for the DAT is quite low.