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- Title
TRPA1 agonists delay gastric emptying in rats through serotonergic pathways.
- Authors
Doihara, Hitoshi; Nozawa, Katsura; Kawabata-Shoda, Eri; Kojima, Ryosuke; Yokoyama, Toshihide; Ito, Hiroyuki
- Abstract
Our recent study found that TRPA1 is highly expressed in enterochromaffin cells and that stimulation of these cells with TRPA1 agonists enhances 5-hydroxytryptamine (5-HT) secretion in vitro. Here, to demonstrate the 5-HT-releasing effect of TRPA1 agonists in vivo, we examined the effect of TRPA1 agonists on gastric emptying in rats. The results showed that TRPA1 agonists dose-dependently delayed gastric emptying. Further, the effects of TRPA1 agonists on this delay were abolished in rats treated with a TRPA1 antagonist, an inhibitor of tryptophan hydroxylase, or a 5-HT(3) receptor antagonist. Taken together, these results indicate that TRPA1 agonists delay in vivo gastric emptying through serotonergic pathways.
- Publication
Naunyn-Schmiedeberg's archives of pharmacology, 2009, Vol 380, Issue 4, p353
- ISSN
1432-1912
- Publication type
Journal Article
- DOI
10.1007/s00210-009-0435-7