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- Title
Association of hOGG1 genotype with life style and oxidative DNA damage among Chinese ethnic populations.
- Authors
Yuebin Ke; Zhunzhen Zhang; Youshen Jiang; Zhixiong Zhuang; Lu Li; Wenqing Lu; Tangchun Wu
- Abstract
To assess the natural variation of hOGG1 gene and the gene–environmental interactions, the hOGG1 codon 326 polymorphism and urinary 8-OHdG levels were investigated in large samples ( n = 953) of healthy individuals from five Chinese ethnic populations by using PCR-RFLP and HPLC-ECD. Life-style parameters under study were obtained through a questionnaire. The allelic frequencies of the hOGG1 gene in the Chinese populations were found to be 0.16 (Ser/Ser), 0.49 (Ser/Cys) and 0.35 (Cys/Cys), respectively. The frequencies of Ser326Cys polymorphism were significantly different among the five Chinese ethnic populations ( P = 0.002). No association was found between the hOGG1 gene polymorphism and other life-style parameters except for the association between Ser326Cys and smoking ( P = 0.027). A significant increase of urinary 8-OHdG level was observed in Cys326Cys allelic healthy subjects ( P = 0.033). These results suggest that there are natural variations of hOGG1 gene among Chinese ethnic populations. Smoking relates to Cys/Cys polymorphism frequencies, and oxidative DNA damage is repaired less in individuals with the hOGG1 Cys326Cys genotype.
- Publication
Archives of Toxicology, 2009, Vol 83, Issue 7, p663
- ISSN
0340-5761
- Publication type
Academic Journal
- DOI
10.1007/s00204-009-0421-3