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- Title
Changes in cortical bone response to high-fat diet from adolescence to adulthood in mice.
- Authors
Ionova-Martin, S S; Wade, J M; Tang, S; Shahnazari, M; Ager, J W, 3rd; Lane, N E; Yao, W; Alliston, T; Vaisse, C; Ritchie, R O
- Abstract
Diabetic obesity is associated with increased fracture risk in adults and adolescents. We find in both adolescent and adult mice dramatically inferior mechanical properties and structural quality of cortical bone, in agreement with the human fracture data, although some aspects of the response to obesity appear to differ by age.
- Publication
Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2011, Vol 22, Issue 8, p2283
- ISSN
1433-2965
- Publication type
Journal Article
- DOI
10.1007/s00198-010-1432-x