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- Title
An increased alveolar CD4 + CD25 + Foxp3 + T-regulatory cell ratio in acute respiratory distress syndrome is associated with increased 30-day mortality.
- Authors
Adamzik, Michael; Broll, Jasmin; Steinmann, Jörg; Westendorf, Astrid Maria; Rehfeld, Irene; Kreissig, Carla; Peters, Jürgen
- Abstract
Cell therapy may become an option for lung injury treatment. However, no data are available on the alveolar presence and time course of CD4+ CD25 + Foxp3 + T-regulatory lymphocyte cells (Tregs) in acute respiratory distress syndrome (ARDS). Accordingly, we (1) measured the ratio of CD4 + CD25 + Foxp3 + Tregs to all (CD4+) lymphocytes in the bronchoalveolar lavage (BAL) of ARDS patients and of control subjects without lung disease and (2) assessed their impact on 30-day mortality.
- Publication
Intensive care medicine, 2013, Vol 39, Issue 10, p1743
- ISSN
1432-1238
- Publication type
Journal Article
- DOI
10.1007/s00134-013-3036-3