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- Title
Elevated preoperative serum asymmetrical dimethylarginine (ADMA) is associated with poor outcomes after pediatric cardiac surgery.
- Authors
Hassinger, Amanda B; Wainwright, Mark S; Lane, Jerome C; Haymond, Shannon; Backer, Carl L; Wald, Eric
- Abstract
Asymmetrical dimethylarginine (ADMA), an endogenous competitive inhibitor of nitric oxide synthase, is elevated in vascular pathologies such as hypertension and chronic kidney disease. Children undergoing cardiac surgery are at high risk of poor hemodynamic and renal outcomes secondary to cardiopulmonary bypass (CPB). This study tested the hypothesis that elevated preoperative ADMA levels are associated with overall worse clinical outcomes after pediatric CPB.
- Publication
Intensive care medicine, 2012, Vol 38, Issue 10, p1697
- ISSN
1432-1238
- Publication type
Journal Article
- DOI
10.1007/s00134-012-2657-2