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- Title
Effects of anesthetic regimes on inflammatory responses in a rat model of acute lung injury.
- Authors
Fortis, Spyridon; Spieth, Peter M; Lu, Wei-Yang; Parotto, Matteo; Haitsma, Jack J; Slutsky, Arthur S; Zhong, Nanshan; Mazer, C David; Zhang, Haibo
- Abstract
Gamma-aminobutyric acid (GABA) is the major inhibitory neurotransmitter through activation of GABA receptors. Volatile anesthetics activate type-A (GABA(A)) receptors resulting in inhibition of synaptic transmission. Lung epithelial cells have been recently found to express GABA(A) receptors that exert anti-inflammatory properties. We hypothesized that the volatile anesthetic sevoflurane (SEVO) attenuates lung inflammation through activation of lung epithelial GABA(A) receptors.
- Publication
Intensive care medicine, 2012, Vol 38, Issue 9, p1548
- ISSN
1432-1238
- Publication type
Journal Article
- DOI
10.1007/s00134-012-2610-4