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- Title
Immunoparalysis and nosocomial infection in children with multiple organ dysfunction syndrome.
- Authors
Hall, Mark W; Knatz, Nina L; Vetterly, Carol; Tomarello, Steven; Wewers, Mark D; Volk, Hans Dieter; Carcillo, Joseph A
- Abstract
Immunoparalysis defined by prolonged monocyte human leukocyte antigen DR depression is associated with adverse outcomes in adult severe sepsis and can be reversed with granulocyte macrophage colony-stimulating factor (GM-CSF). We hypothesized that immunoparalysis defined by whole-blood ex vivo lipopolysaccharide-induced tumor necrosis factor-alpha (TNFα) response <200 pg/mL beyond day 3 of multiple organ dysfunction syndrome (MODS) is similarly associated with nosocomial infection in children and can be reversed with GM-CSF.
- Publication
Intensive care medicine, 2011, Vol 37, Issue 3, p525
- ISSN
1432-1238
- Publication type
Journal Article
- DOI
10.1007/s00134-010-2088-x