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- Title
NGF-withdrawal induces apoptosis in pancreatic beta cells in vitro.
- Authors
Pierucci, D; Cicconi, S; Bonini, P; Ferrelli, F; Pastore, D; Matteucci, C; Marselli, L; Marchetti, P; Ris, F; Halban, P; Oberholzer, J; Federici, M; Cozzolino, F; Lauro, R; Borboni, P; Marlier, L N
- Abstract
Using primary cultures of human pancreatic islets, purified human pancreatic beta cells and the mouse beta TC6-F7 cell line, we analysed the expression of nerve growth factor, (NGF/NGF) receptors in beta cells. To investigate whether NGF could sub-serve an autocrine antiapoptotic role in beta cells, we studied the effects of NGF withdrawal using a neutralizing monoclonal anti-NGF antibody.
- Publication
Diabetologia, 2001, Vol 44, Issue 10, p1281
- ISSN
0012-186X
- Publication type
Journal Article
- DOI
10.1007/s001250100650