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- Title
Detection of nitrotyrosine in the diabetic plasma: evidence of oxidative stress.
- Authors
Ceriello, A; Mercuri, F; Quagliaro, L; Assaloni, R; Motz, E; Tonutti, L; Taboga, C
- Abstract
Oxidative stress plays an important role in diabetic vascular complications. It has been shown that an imbalance in the ratio of nitric oxide: superoxide anion, because of a prevalence of superoxide anion, leads to an alteration in vascular reactivity. In this condition peroxynitrite production, resulting from the reaction between nitric oxide and superoxide, could increase. Peroxynitrite is responsible for nitration of tyrosine residues in proteins. Therefore, the presence of nitrotyrosine in plasma proteins is considered indirect evidence of peroxynitrite production. The aim of this study was to demonstrate the presence of nitrotyrosine in the plasma of patients with Type II (non-insulin-dependent) diabetes mellitus and to correlate its concentrations with the plasma concentrations of glucose and antioxidant defenses.
- Publication
Diabetologia, 2001, Vol 44, Issue 7, p834
- ISSN
0012-186X
- Publication type
Journal Article
- DOI
10.1007/s001250100529