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- Title
Angiotensin converting enzyme inhibition reduces retinal overexpression of vascular endothelial growth factor and hyperpermeability in experimental diabetes.
- Authors
Gilbert, R E; Kelly, D J; Cox, A J; Wilkinson-Berka, J L; Rumble, J R; Osicka, T; Panagiotopoulos, S; Lee, V; Hendrich, E C; Jerums, G; Cooper, M E
- Abstract
Angiotensin converting enzyme (ACE) inhibition has been recently suggested to have retinoprotective actions in diabetic patients but the mechanism of this effect is not known. In vitro, angiotensin II stimulates expression of vascular endothelial growth factor (VEGF), a permeability-inducing and endothelial cell specific angiogenic factor which has been implicated in the pathogenesis of diabetic retinopathy in humans and in experimental animals. We sought to determine the effects of ACE inhibition on retinal VEGF expression and permeability in experimental diabetic retinopathy.
- Publication
Diabetologia, 2000, Vol 43, Issue 11, p1360
- ISSN
0012-186X
- Publication type
Journal Article
- DOI
10.1007/s001250051539